Estimation of allele frequencies at isoloci.

Estimation of allele frequencies at isoloci.

In some polyploid animals and plants, pairs of duplicated loci occur that share alleles encoding proteins with identical electrophoretic mobilities. Except in cases where these "isoloci" are known to be inherited tetrasomically, individual genotypes cannot be determined unambiguously, and there is no direct way to assign observed variation to a particular locus of the pair. For a pair of dialle...

Improving the estimation of bacterial allele frequencies.

RANNALA et al. (2000) develop a useful Poisson proand also simplifies the estimation of p and as described in estimation from the whole sample of hosts. The cess model for estimating allele frequencies in bacterial populations using presence/absence data on inMLEs derived in both of the following sections are shown to be less biased than the estimators given in fected hosts. However, they also ...

Allele Frequencies and Genotype Frequencies

Estimation of allele frequencies from high-coverage genome-sequencing projects.

A new generation of high-throughput sequencing strategies will soon lead to the acquisition of high-coverage genomic profiles of hundreds to thousands of individuals within species, generating unprecedented levels of information on the frequencies of nucleotides segregating at individual sites. However, because these new technologies are error prone and yield uneven coverage of alleles in diplo...

Estimation of allele frequencies with data on sibships.

Allele frequencies are generally estimated with data on a set of unrelated individuals. In genetic studies of late-onset diseases, the founding individuals in pedigrees are often not available, and so one is confronted with the problem of estimating allele frequencies with data on related individuals. We focus on sibpairs and sibships, and compare the efficiency of four methods for estimating a...